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. 2020 Aug 28;11:4334. doi: 10.1038/s41467-020-18171-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Volcano plot showing the dysregulated features in aging mice (36-week vs. 104-week; p-value ≤ 0.05; two-sided Student’s t-test); b heat maps showing age-dependent activities of five enriched KEGG metabolic pathways (left panel) and their related unknowns (right panel); c examples of adenylosuccinic acid and its derived unknown (ExtDB016054) down-regulated in aging mice (n = 10, biologically independent samples for each group; two-sided Student’s t-test); d heat map showing age-dependent activities of 14 enriched chemical subclasses; e annotated unknowns from the subclass of pyrimidines and pyrimidine derivatives down-regulated in aging mice (n = 10, biologically independent samples for each group; two-sided Student’s t-test). The lower, middle, and upper lines in box plots (c, e) correspond to 25th, 50th, and 75th quartiles, and the whiskers extend to the most extreme data point within 1.5 interquartile range (IQR). Source data are provided as a Source Data file.