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. 2020 Aug 28;10:14242. doi: 10.1038/s41598-020-70938-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Biopsy selection and time course of subclinical histological findings. (A) Flow chart outlining availability and selection of biomaterial for this study. (B–E) Prevalence of histological findings (histological criteria for minimization of immunosuppression (HCMini) and at least moderate graft fibrosis), diagnosis (cAMR = possible chronic antibody-mediated rejection; IND = indeterminate findings; NHR = no histological rejection; subTCMR = subclinical T cell-mediated rejection; GH = graft hepatitis not fulfilling cAMR criteria) and graft gene expression signatures (cTCMR = clinical relevant T cell mediated rejection) in liver biopsies with normal/marginally elevated liver enzymes (n = 133) over time. P-values of Chi² test of the prevalence of time are depicted.