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. 2020 Aug 28;10:14242. doi: 10.1038/s41598-020-70938-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Association of DSA with subclinical graft injury and fibrosis. (A) DSA were detected in 39 of 133 samples with normal/marginally elevated liver enzymes. Specificity of DSA and MFI of class I and II DSA (left and middle panel). DSA frequency was increasing over time (right panel). (B) DSAs were associated with a progressive graft hepatitis and fibrosis over time (Y = year; **p < 0.01; ***p < 0.001). (C) Presence of DSA was associated with the severity of graft injury (HCMini = histological criteria of immunosuppression minimization) and at least moderate graft fibrosis. (D) Association of class II DSA with severity of graft injury. Further information on histological scores and DSA are listed in Table 3.