Table 3.
Box–Behnken Design and Results
| No. | Independent Variables | Dependent Variables | |||
|---|---|---|---|---|---|
| A | B | C | Y1 | Y2 | |
| 1 | 5 | 5:1 | 7:1 | 30.41 | 5.61 |
| 2 | 15 | 4:1 | 10:1 | 32.64 | 3.17 |
| 3 | 5 | 4:1 | 10:1 | 31.51 | 6.51 |
| 4 | 10 | 4:1 | 7:1 | 40.78 | 3.84 |
| 5 | 15 | 3:1 | 7:1 | 31.98 | 8.36 |
| 6 | 15 | 5:1 | 7:1 | 28.32 | 4.51 |
| 7 | 5 | 3:1 | 7:1 | 38.82 | 6.77 |
| 8 | 10 | 5:1 | 10:1 | 38.48 | 4.89 |
| 9 | 10 | 5:1 | 4:1 | 32.7 | 3.56 |
| 10 | 5 | 4:1 | 4:1 | 34.05 | 7.03 |
| 11 | 10 | 3:1 | 10:1 | 31.38 | 6.49 |
| 12 | 10 | 4:1 | 7:1 | 43.69 | 6.72 |
| 13 | 10 | 3:1 | 4:1 | 25.54 | 4.10 |
| 14 | 15 | 4:1 | 4:1 | 36.69 | 5.04 |
| 15 | 10 | 4:1 | 7:1 | 40.78 | 3.79 |
| 16 | 10 | 4:1 | 7:1 | 41.88 | 3.25 |
| 17 | 10 | 4:1 | 7:1 | 40.08 | 3.52 |
Notes: Independent variables: A, the dosage of BO (mg); B, the ratio of phospholipid to drug (w/w); C, the ratio of phospholipid to cholesterol (w/w). Dependent variables: Y1: EE(%); Y2: DL(%).