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Based on the morphology and function at different stages, astrocytes in SCI are divided into naïve astrocytes, reactive astrocytes, and scar-forming astrocytes. This is a promising method to inhibit the formation of SAs through blockage of the Col1-N-cadherin pathway before the chronic stage of SCI. Nes: nestin; Cdh2: cadherin 2; Sox9: SRY-box transcription factor 9; Xylt1: xylosyltransferase 1; Ctnnb1: catenin beta 1; Plaur: plasminogen activator, urokinase receptor.
