Table 3.
Factors associated with infant's HBV infection at 12-month follow-up (N = 150).
| Infant's characteristics | Infant with positive HBsAg, n (%) | Crude ORa, OR [95% CI] | Adjusted ORb, OR [95% CI] | p valuec | |
|---|---|---|---|---|---|
| Mother's HBeAg status at delivery | HBeAg (-) | 2 (1.7) | Ref. | Ref. | <0.001 |
| HBeAg (+) | 10 (34.5) | 31.3 [6.4-154.1] | 65.8 [7.3-594.1] | ||
|
| |||||
| Mother's HBV DNA level at delivery | <200,000 IU/mL (106 copies/mL) | 11 (7.6) | Ref. | ||
| ≥200,000 IU/mL (106 copies/mL) | 1 (16.7) | 2.4 [0.3-22.6] | |||
|
| |||||
| Mother's HBV peripartum antiviral therapy | Yes | 1 (3.4) | Ref. | ||
| No | 11 (9.1) | 2.8 [0.3-22.6] | |||
|
| |||||
| Having any family members infected with HBVd | No | 7 (5.5) | Ref. | Ref. | 0.119 |
| Yes | 5 (21.7) | 4.8 [1.4-16.6] | 4.0 [0.7-23.4] | ||
|
| |||||
| Mode of delivery | Vaginal | 8 (8.0) | Ref. | ||
| Caesarean | 4 (8.0) | 1.0 [0.3-3.5] | |||
|
| |||||
| Infant's sex | Female | 7 (9.7) | Ref. | ||
| Male | 5 (6.4) | 1.6 [0.5-5.2] | |||
|
| |||||
| Infant's HBV birth dose vaccination | Yes | 11 (7.4) | Ref. | Ref. | 0.057 |
| No | 1 (50.0) | 12.5 [0.7-212.9] | 36.1 [0.9-1459.5] | ||
|
| |||||
| Infant's HBIG immunization | Yes | 7 (5.7) | Ref. | Ref. | 0.181 |
| No | 5 (18.5) | 3.8 [1.1-12.9] | 3.4 [0.6-19.9] | ||
|
| |||||
| Infant's scheduled HBV vaccination | Completed | 10 (7.0) | Ref. | Ref. | 0.593 |
| Uncompleted | 2 (25.0) | 4.4 [0.8-24.7] | 2.1 [0.1-31.2] | ||
|
| |||||
| Infant feeding (during 12 months of age) | Breast-fed only | 4 (8.5) | Ref. | ||
| Bottle-fed (and/or other food) | 3 (5.8) | 0.7 [0.1-3.1] | |||
| Mixed (breast-fed+bottle-fed and/or other food) | 5 (9.8) | 1.2 [0.3-4.6] | |||
aUnivariate analysis; bmultiple logistic regression; clikelihood-ratio test; dincluding infant's father HBV infection status. OR: odds ratio; CI: confidence interval. α < 0.05.