Table 1.
Associations between lipid profile and laboratory parameters in SCA patients.
| Laboratory parameters | Total cholesterol < 118 mg/dL (N = 64) | Total cholesterol ≥ 118 mg/dL (N = 62) | p value |
|---|---|---|---|
| Basophil (mL) | 111.02 ± 107.40 | 76.69 ± 106.97 | 0.035 |
| LDL-C (mg/dL) | 47.98 ± 11.40 | 77.44 ± 18.63 | 0.000 |
| VLDL-C (mg/dL) | 19.41 ± 9.04 | 25.67 ± 12.42 | 0.000 |
| Triglycerides (mg/dL) | 94.17 ± 39.24 | 124.97 ± 55.95 | 0.000 |
| Direct bilirubin (mg/dL) | 0.38 ± 0.14 | 0.44 ± 0.16 | 0.021 |
| Indirect bilirubin (mg/dL) | 2.91 ± 1.74 | 2.32 ± 1.47 | 0.046 |
| HbF (%) | 10.37 ± 5.97 | 7.87 ± 5.14 | 0.015 |
| HDL‐C < 40 mg/dL (N = 89) | HDL‐C ≥ 40 mg/dL (N = 37) | ||
| Hemoglobin (g/dL) | 8.26 ± 0.99 | 8.99 ± 1.00 | 0.001 |
| Hematocrit (%) | 24.50 ± 3.25 | 26.85 ± 3.24 | 0.001∗ |
| RDW (%) | 23.14 ± 3.83 | 21.54 ± 3.52 | 0.027∗ |
| Eosinophil (mL) | 561 ± 548 | 326 ± 249 | 0.011 |
| Total cholesterol (mg/dL) | 118.27 ± 25.18 | 128.17 ± 22.96 | 0.025 |
| VLDL-C (mg/dL) | 24.32 ± 11.53 | 18.22 ± 9.65 | 0.001 |
| Triglycerides (mg/dL) | 119.43 ± 55.14 | 85.37 ± 25.01 | 0.001 |
| GGT (U/L) | 26.16 ± 23.31 | 30.7 ± 20.4 | 0.035 |
| LDH (U/L) | 1358.3 ± 1513.8 | 984.6 ± 355.8 | 0.006 |
| Ferritin (ηg/mL) | 362.85 ± 506.69 | 482.64 ± 426.72 | 0.035 |
| NOm (μM) | 26.38 ± 15.91 | 17.45 ± 5.52 | 0.001 |
| HbF (%) | 8.43 ± 5.60 | 10.73 ± 5.80 | 0.044 |
| LDL‐C < 58.8 mg/dL (N = 65) | LDL‐C ≥ 58.8 mg/dL (N = 61) | ||
| MCV (fL) | 94.63 ± 11.45 | 90.07 ± 11.44 | 0.028∗ |
| MCH (ρg/mL) | 32.10 ± 3.91 | 30.52 ± 3.91 | 0.025∗ |
MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin; GGT: gamma-glutamyl transferase; RDW: red cell distribution width; LDH: lactate dehydrogenase; HbS: hemoglobin S; HbF: fetal hemoglobin; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; VLDL-C: very low-density lipoprotein cholesterol; NOm: nitric oxide metabolites. p value obtained using Mann-Whitney U test. ∗p value obtained using independent t-test.