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. 2020 Aug 28;20:418. doi: 10.1186/s12935-020-01509-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — TRIB3-siRNA inhibited proliferation and induced apoptosis and cell cycle arrest in ovarian cancer cells. a The expression of TRIB3 protein in five OC cell lines using western blot. b Downregulation of TRIB3 protein using western blot. c TRIB3-siRNA inhibited cell proliferation of ovarian cancer cells. d TRIB3-siRNA increased apoptosis of ovarian cancer cells. e G0/G1 phase arrest of ovarian cancer cells after TRIB3 siRNA transfection. f Western blot analysis showed that the expression of PCNA, Bcl2/Bax, cyclin D1 protein in ovarian cancer cells decreased after transfection with TRIB3-siRNA. For western blot, GAPDH was used as an internal control. Data are presented as mean ± SD. *P < 0.05; **P < 0.01; ***P < 0.001