Table 1.
Characteristics of included studies
| Author | Year | Region | Total | No. of wounds | Species/strain | Gender/weight(g) | Age | Model | Cell type | Dosage | AD | Timing (post burn) | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MSC | Con | ||||||||||||
| Xue | 2013 | China | 60 | 30 | 30 | Mice/ICR | M/NA | 8–10 W | Partial thickness (3–5% TBSA), 90 °C water for 3 s | H-BMSCs | 1 × 106 cells/wound | Local injection | Immediately |
| Karimi | 2014 | Iran | 18 | 9 | 9 | Mice/Balb/c | M/40 | NA | Full thickness, a 96 °C needle for 8 s | M-ADSCs | 1 × 106 cells/wound | Local injection | Immediately |
| Loder | 2015 | USA | 10 | 5 | 5 | Mice/C57BL/6 | M/NA | 26–28 W | Partial thickness (30% TBSA), 60 °C water for 17 s | Syngenic M- ADSCs | 1 × 106 cells/wound | Local injection | 24 h |
| Bliley | 2016 | USA | 24 | 12 | 12 | Mice/athymic nude | F/NA | 7–9 W | Full thiness, a 70 °C brass stamp for 10s | H-ADSCs | 6.8 × 106 cells/wound | Local injection | 24 h |
| Shumakov | 2003 | Russian | 30 | 20 | 10 | Rat/Wistar | M/(300–350) g | Adult | Full thiness (18–20% TBSA), a 97.7 °C metal plate for 8 s | Auto/Allogenic R-BMSCs | 2 × 106 cells/wound | NA | 48 h |
| Singer* | 2013 | USA | 20 | 20 | 20 | Rat/Sprague-Dawley | M/(300–400) g | NA | Full thiness, a 100 °C brass comb for 30s | R-BMSCs | 1 × 106 cells/wound | Tail vein | 60 m |
| Liu | 2014 | China | 84 | 42 | 42 | Rat/Wistar | M/(180–220) g | 6 W | Full thiness (30% TBSA), 94 °C water for 12 s | H-UCMSCs | 5 × 106 cells/wound | Tail vein | 72 h |
| Zhang | 2015 | China | 84 | 42 | 42 | Rat/Sprague-Dawley | M/(200 ± 5) g | NA | Full thiness, burned iron for 25 s | H-UCMSCs | 2 × 106 cells/animal | Local injection | 24 h |
| Clover* | 2015 | Ireland | 3 | 36 | 36 | Pig/Landrace | F/(25–30) kg | NA | Partial thickness (5% TBSA), a 80 °C brass block for 30 s | Allogenic P-BMSCs | 4.5 × 106 cells/wound | Cover | Immediately |
| Abbas | 2018 | Turkey | 50 | 20 | 20 | Rat/Wistar | M/(300–325) g | Adult | Thickness unavailable, a 100 °C brass comb for 30 s | R-BMSCs | 1 × 106 cells/wound | Local injection | 30 m |
| Alapure | 2018 | New Orleans | 8 | 4 | 4 | Mice/C57BL/6 J | F/NA | 9 W | Full thiness, a 100 °C alloy-aluminum-rod for 4 s | M-BMSCs seeded AC gels | 1 × 105 cells/wound | Local injection | 48 h |
| Banerjee | 2019 | USA | 8 | 4 | 4 | Rat/Harlan | M/NA | 8–10 W | Partial thickness, a 87 °C brass for 10s | R-ADSCs | 5 × 104 cells/wound | Local injection | 9d |
| Chang* | 2018 | Taiwan | 20 | 28 | 12 | Rat/Wistar | M/(176–250) g | 6–7 W | Full thiness (20% TBSA), a 95 °C metal rod | R-ADSCs | 5 × 106 cells/wound | Local injection | 24 h |
| Feng* | 2019 | Taiwan | 6 | 9 | 9 | Rat/Sprague-Dawley | NA/(250–300) g | NA | Partial thickness, a 90 °C copper plate for 30 s | R-ADSCs | 5 × 105 cells/wound | Local injection | 30 m |
| Foubert* | 2018 | USA | 15 | 16 | 14 | Pig/Yorkshire swine | F/(80–130) g | 4-6 M | Full thickness/Partial thickness (<10% TBSA), a 180–200 °C brass template for 30 s/60 s | Autologous P-ADSCs | 0.5 × 106 cells/kg | Local injection | 5 m |
| Kaita | 2019 | Japan | 24 | 12 | 12 | Mice/BALB/c Nude | M/NA | 6–8 W | Full thickness, a 150 °C for 5 s | H-ADSCs | 5 × 104 cells/wound | Local injection | 1 h |
| Mahmood* | 2018 | Pakistan | 12 | 12 | 12 | Rat/Sprague-Dawley | NA/NA | 9–12 M | Full thickness, a 100 °C brass rod (2x2cm) for 20s | H-UCMSCs | 3 × 104 cells/wound | Cover | 48 h |
| Oryan* | 2019 | Iran | 8 | 16 | 16 | Rat/Sprague-Dawley | M/(200 ± 20)g | 7–9 W | Full thickness, a 100 °C aluminum bar for 10 s | Allogenic R-ADSCs | 1 × 106 cells/wound | Local injection | 48 h |
| Yang | 2018 | China | 40 | 30 | 10 | Mice/BALB/c | M/F/NA | Adult | Full thickness, a 100 °C copper plate tip for 10 s | H-UCMSCs | 8 × 105 cells/wound | Local injection | 5 m |
| Liao | 2019 | China | 72 | 24 | 24 | Rat/Sprague-Dawley | M/NA | 8 W | Partial thickness, 100 °C water | M-ADSCs | 2 × 106 cells/wound | Cover | NA |
USA United States of America, MSC mesenchymal stem cells, Con control, AD administration, TBSA total body surface area, H-BMSCs human bone marrow stem cells, M-ADSCs mouse adipose-derived mesenchymal stem cells, H-ADSCs human adipose-derived mesenchymal stem cells, R-BMSCs rat bone marrow stem cells, H-UCMSCs human umbilical cord mesenchymal stem cells, P-BMSCs pig bone marrow stem cells, M-BMSCs mouse bone marrow stem cells, R-ADSCs rat adipose-derived mesenchymal stem cells, P-ADSCs pig adipose-derived mesenchymal stem cells, W week, M month, M male, F female, NA not available, m minute, h hour, d day
*Means there are more than one burn wounds in a rat, mouse, or pig