Fig. 9.

Influence of the Crt C domain on Tsn TC conformational dynamics. (A) Tsn TC is lodged between MHC-I ${\alpha }_3$ and ${\beta }_2\text{m}$ and also contacted by the Crt C domain. (B) ${\text{C}}_{\alpha }$ rmsd of TC using TN ${\text{C}}_{\alpha }$ for structural superposition. (C) The average plane of the TC $\beta$-sheet region that contacts MHC-I (residues 273 to 277, 293 to 298, 327 to 329, 341 to 346) is used to measure TC rotation. (D) Angle $\theta$ of the $\beta$-sheet to its initial orientation, viewed from the top of the ER-luminal part of the PLC toward the membrane.