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Antibiotics that bind in the decoding center on the small ribosomal subunit. (A and B) The location of the SAR binding site relative to the binding sites of other antibiotics known to target the decoding center of the small ribosomal subunit: TET (blue), negamycin (NEG, red), odilorhabdin NOSO-641 (ODL, green), streptomycin (STR, cyan), paromomycin (PAR, salmon). In B, the 16S rRNA nucleotides critical for decoding are shown as sticks.
