Fig. 1.

The CIC-DUX4 binding landscape in undifferentiated sarcoma. (A) Genome-wide annotation of endogenous CIC-DUX4 ChIP-seq peak intensity in sarcoma cell line NCC_CDS_X1. Vertical bars represent CIC-DUX4 oncoprotein binding peaks on labeled chromosomes (corresponding chromosome number on the right). The x-axis corresponds to the genomic location, and the y-axis quantifies the number of reads within each peak. (B) Relative frequency of CIC-DUX4 binding sites in annotated genomic regions. (C) Functional enrichment analysis of putative CIC-DUX4 target genes. The significance is shown on the x-axis as −log10(P value). (D) Integrative Genomic Viewer showing CIC-DUX4 binding peaks upstream of the TSSs at genes DUSP6 and DUSP4.