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. 2020 Aug 29;156:133–187. doi: 10.1016/j.addr.2020.08.008

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© 2020 Published by Elsevier B.V.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 18 — Design and efficacy of CP-DOX nanoparticles. (A) ELPs are conjugated to DOX at Cys residues via a heterobifunctional linker. (B) CP nanoparticles self-assemble to entrap hydrophobic DOX in the core and display the hydrophilic polypeptide on the corona. (C) DOX release from CP-DOX is pH-dependent. (D, E) CP-DOX formulation promotes DOX accumulation in the tumor while reducing its presence in heart tissue. (F) A single injection of CP-DOX outperforms free DOX in reducing tumor volume. Adapted with permission from [354].