Table 2.
Univariate analysis: factors associated with the continuation or modification of anticancer therapy in intensive care unit survivors
| Variables | ACT continued (n = 32) | ACT modified (n = 33) | P |
|---|---|---|---|
| Age, years | 57 (50–65) | 57 (44–66) | 1.000 |
| Gender (male), n (%) | 20 (63) | 22 (67) | 0.725 |
| Comorbidities | |||
| Chronic heart failure, n (%) | 0 (0) | 4 (12) | 0.114 |
| Chronic respiratory disease, n (%) | 1 (3) | 2 (6) | 1.000 |
| Charlson comorbidity index | 3 (2–4) | 3 (2–4) | 0.689 |
| Karnofsky performance status at admission | 70 (60–80) | 70 (50–80) | 0.349 |
| Disease status at admission | |||
| Cancer progression, n (%) | 13 (41) | 26 (79) | 0.002 |
| Grade IV, n (%) | 20 (63) | 28 (85) | 0.040 |
| IDH1/2 mutation, n (%) | 3 (9) | 2 (6) | 0.661 |
| 1p/19q codeletion, n (%) | 2 (6) | 0 (0) | 0.502 |
| Anticancer therapy received at admission | 25 (78) | 31 (94) | 0.082 |
| Chemotherapy, n (%) | 23 (72) | 26 (79) | 0.518 |
| Radiotherapy, n (%) | |||
| Corticosteroid therapy n (%) | 19 (59) | 30 (91) | 0.004 |
| Reason for admission | |||
| Coma with seizures, n (%) | 18 (56) | 14 (42) | 0.265 |
| Coma without seizures, n (%) | 3 (9) | 5 (15) | 0.709 |
| Acute respiratory failure, n (%) | 6 (19) | 6 (18) | 0.953 |
| Shock, n (%) | 2 (6) | 4 (12) | 0.672 |
| Other, n (%) | 3 (9) | 4 (12) | 1.000 |
| Severity at admission | |||
| SAPSII | 39 (17–51) | 29 (20–38) | 0.423 |
| SOFA | 4 (3–6) | 5 (3–7) | 0.389 |
| Physiological variables at admission | |||
| Glasgow coma scale | 9 (7–14) | 8 (6–14) | 0.796 |
| Heart rate, beats/min | 92 (80–107) | 97 (81–105) | 0.948 |
| Systolic blood pressure, mmHg | 116 (105–126) | 130 (108–141) | 0.056 |
| Respiratory rate, cycles/minute | 20 (17–22) | 22 (19–24) | 0.263 |
| Temperature, °C | 37 (36–37) | 37 (37–38) | 0.311 |
| Laboratory variables at admission | |||
| Leukocyte count, 109/L | 9.2 (6.5–13,330) | 7.1 (5.0–11.5) | 0.042 |
| Neutropenia, n (%) | 0 (0) | 2 (6) | 0.492 |
| Serum creatinine, μmol/L | 67 (50–86) | 70 (47–100) | 0.778 |
| Arterial blood gases | |||
| pH | 7.41 (7.35–7.47) | 7.41 (7.37–7.44) | 0.738 |
| PaCO2, mmHg | 39 (33–44) | 36 (31–41) | 0.299 |
| PaO2/FiO2 | 331 (274–392) | 300 (247–380) | 0.487 |
| Life-sustaining intervention | |||
| Mechanical ventilation, n (%) | 14 (44) | 15 (45) | 0.890 |
| Vasopressor, n (%) | 3 (9) | 8 (24) | 0.239 |
| Renal replacement therapy, n (%) | 1 (3) | 0 (0) | 0.492 |
Continuous variables are expressed as median (interquartile interval) and categorical variables are expressed as numbers (%]
SAPS II Simplified Acute Physiology Score II; SOFA Sequential Organ Failure Assessment,