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. 2020 Aug 10;130(9):4906–4920. doi: 10.1172/JCI133953

Figure 3. CSF concentrations of psychosine and galactosylceramide.

Figure 3

Psychosine (A) and galactosylceramide (GalCer) (B) were measured by mass spectrometry every 4 weeks up to 52 weeks of age. Psychosine and GalCer are reported in ng/mL. Psychosine was below the level of detection in normal dogs. Gray shading indicates normal range for canine samples collected at the cisterna magna (<10 ng/mL) for GalCer. IS-only (n = 4, gray circles), 2Wk-High (n = 10, ≤16 weeks of age; n = 6, >16 weeks of age; red triangles), 2Wk-Low (n = 4, ≤16 weeks of age; n = 3, >16 weeks of age; blue triangles). Lines represent mean with SEM. Nonparametric Kruskal-Wallis test and Mann-Whitney test were performed. A P value of less than 0.05 was considered significant.