Figure 2. R47H variant of TREM2 decreases neurodegeneration in 9-month-old PS19 mice.

(A) Representative images of PS19-T2^CV and PS19-T2^R47H brain sections stained with Sudan black at 9 months of age. Scale bars: 1 mm. (B–E) Quantification of the average volume of the hippocampus (B), ventricles (C), entorhinal and piriform cortices (D), and half brain minus ventricle (E). (F–I) Thickness of the pyramidal layer of the piriform cortex (F and H) and the granule cell layer of the dentate gyrus (DG) (G and I) in 9-month-old mice with cresyl violet staining. Data are presented as mean ± SEM. Significance was determined by an unpaired, 2-tailed Student’s t test. *P < 0.05, **P < 0.01 (9-month-old: PS19-T2^CV, n = 18/19 and PS19-T2^R47H, n = 16).