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. 2020 Aug 10;130(9):4921–4934. doi: 10.1172/JCI138392

Figure 3. Peritoneal administration of TCMCB07 diminishes anorexia in rats with cancer cachexia.

Figure 3

(A) Schematic of experimental design. (B) Daily food intake in tumor/saline group (n = 9), tumor/TCMCB07 group (n = 8), and sham/saline group (n = 6) after tumor implantation or sham operation. Rats received i.p. injection once daily with saline or TCMCB07 (3 mg/kg/d) between days 7 and 12 after implantation. (C) Cumulative food intake after saline or TCMCB07 treatment. (D) Body weight gain (%, tumor-free net gain normalized to baseline of day 7) after saline or TCMCB07 treatment. (E) Tumors were dissected and weighed after animals were euthanized on day 14. All data in B are expressed as mean ± SEM for each group, and all data in C–E are expressed with each dot representing 1 sample. Two-way ANOVA in B and sham/saline group was excluded from 2-way ANOVA analysis in order to clearly show a treatment comparison between 2 tumor groups (tumor/TCMCB07 versus tumor/saline). **P < 0.01; ***P < 0.001; ****P < 0.0001, 1-way ANOVA (C and D); unpaired Student’s t test (E). Red asterisks in B indicate tumor/TCMCB07 group versus tumor/saline group.