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. 2020 Jul 27;130(9):4546–4560. doi: 10.1172/JCI136068

Figure 9. Model of FTY720 versus BAF312 action on cryptococcal reactivation.

Figure 9

(A) When FTY720 is administered, the FTY720-phosphate (FTY720P) affects S1PR3 (along with S1PR1, S1PR4, and S1PR5; not illustrated). This leads to decreased phagocytosis, intracellular killing, and ROS production, which disrupt the maintenance of the granuloma. Fungal cells are able to replicate and escape to cause a reactivation. Granuloma structure is altered; macrophages are found outside of the fibrotic granuloma layer and those remaining inside the granuloma show an M2 polarization. (B) When BAF312 is administered, S1PR3 signaling is unaffected, granuloma organization is maintained, and no reactivation takes place.