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. 2020 Aug 17;130(9):4947–4953. doi: 10.1172/JCI139569

Figure 4. Electron microscopic images of coronavirus particles in different placental cell types.

Figure 4

(A) Schematic illustration of chorionic villi. Cytotrophoblasts, syncytiotrophoblasts, fibroblasts, and endothelial cells are indicated in pink, purple, yellow, and red, respectively. (B) Cytotrophoblast (on the left with the nucleus) and syncytiotrophoblast (on the right). Scale bar: 500 nm. (C) Enlarged image of boxed area in B. Cytoplasm of a syncytiotrophoblast cell with virus particles (red arrowheads). Scale bar: 100 nm. (D) Cytoplasm of a cytotrophoblast cell with virus particles indicated by red arrowheads. Scale bar: 500 nm and 100 nm (insert). (E–H) Fibroblast with virus particles indicated by red arrowheads. Scale bars: 100 nm (E), 500 nm (F) (insert, 100 nm), 100 nm (G) (insert, 100 nm), 100 nm (H). (I) Endothelial cell within chorionic villus with budding viral particles indicated by red arrowheads. Scale bar: 100 nm.