Table 2.
Results of Systematic Review with Cohort Studies of COVID-19 Positive Patients – Characteristics of Stroke, Treatment, and Mortality.
| Study | Ischemic, % (N) | Days from COVID-19 symptom onset | Laboratory data |
Etiology |
Treatment |
Mortality, % (N) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D-dimer (μg/mL) | CRP (mg/L) | Cardiac troponin (ng/mL) | Cryptogenic | Cardioembolic | Atherothrombic | tPA | Mechanical thrombectomy | AC | ||||
| Mao et al. | 83.3% (5) | 9 [range 1-18]* | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Lodigiani et al. | 100% (9) | NA | 3.6 [0.4, 6.3] | NA | NA | NA | NA | NA | 22.2% (2) | 22.2% (2) | 88.9% (8) | NA |
| Yaghi et al. | 100% (32) | 10 [5, 16.5] | 3.913 [2.549-10.000] | 101.1 [38.8, 214.3] | 0.7 [0.3125, 1.36]*3 | 65.6% (21) | 21.9% (7) | 6.3% (2) | 12.5% (4) | 21.9% (7) | 78.1% (25) | 37.5% (12) |
| Cantador et al. | 100% (8) | 6.3±5.4 | 2.589 [0.735, 8.156] | 100.5 [27, 206] | NA | 25% (2) | 25% (2) | 37.5% (8) | 12.5% (1) | NA | Prophylactic 37.5% (3), therapeutic 12.5% (2) | 25% (2) |
| Romero Sanchez et al. | NA | 10⁎2 | 9.929±28.286 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Merkler et al. | NA | 16 [5, 28] | 1.93 [0.559, 5.285] | NA | 0.03 [0.03, 0.09] | 51.6% (16) | 41.9% (13) | NA | 9.7% (3) | 6.5% (2) | NA | 29% (9) |
| Klok et al. | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Radmanesh et al. | 100% (13) | NA | NA | NA | NA | NA | NA | NA | NA | 23.1% (3) | NA | NA |
| Escalard et al. | 100% (10) | 6 [range 2-18]* | NA | NA | NA | NA | NA | NA | 50% (5) | 100% (10) | NA | 60% (6) |
| Kihira et al. | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
Days from COVID-19 symptom onset, D-dimer, C-reactive protein (CRP), cardiac troponin – shown as median [Q1, Q3] or mean±SD unless specified otherwise. *1 – specified as “range” in the original article. *2 - mean. *3 - Only 15 patients out of 32 patients had available value in the article. AC – anticoagulation; NA – non-applicable; tPA – tissue plasminogen activator.