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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: J Endocrinol. 2020 Oct;247(1):39–52. doi: 10.1530/JOE-20-0052

Figure 1. IRKOGFAP mice exhibit sex differences in insulin sensitivity and glucose tolerance over time.

Figure 1.

(A) Insulin tolerance test (ITT) measurements of blood glucose levels for females (n=9–14 per group) and males (n=9–13 per group) after peripheral insulin injections (0.75U/kg IP) at 2 months of age. (B) ITT measurements of blood glucose levels for females (n= 6–8 per group) and males (n=7 per group) after peripheral insulin injections at 7 months of age. (C) Area under curve (AUC) measurements of ITT for females and males at 2 months and 7 months of age. (D) Glucose tolerance test (GTT) measurements of blood glucose levels for females (n=10 per group) and males (n=9–11 per group) after peripheral glucose injection (2g/kg) at 2 months of age. (E) GTT measurements of blood glucose levels for females (n=6–8 per group) and males (n=7 per group) after peripheral glucose injection at 7 months of age. (F) Area under curve (AUC) measurements of GTT for females and males at 2 months and 7 months of age. The female IRloxp group is represented with light pink line/dots, female IRKOGFAP group with dark pink line/dots, male IRloxp group with light blue line/dots and male IRKOGFAP group with dark blue line/dots. Values are expressed as means ± SEM. * P<0.0332, * * P<0.0021, *** P<0.0002, **** P< 0.0001 by three-way ANOVA and Tukey post-hoc test relative to IRKOGFAP versus IRloxp groups.