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. 2019 Aug 13;41(3):267–273. doi: 10.1093/carcin/bgz139

Table 2.

The association of mtDNA copy number with BCR

	No BCR	BCR	Adjusted HR^a (95% CI)	P value	Adjusted HR^b (95% CI)	P value
mtDNAcn	N (%)	N (%)
By median
High	138 (86.79)	21 (13.21)	Reference		Reference
Low	150 (94.94)	8 (5.06)	0.35 (0.14–0.86)	0.022	0.32 (0.13–0.79)	0.014
By tertile
High	92 (86.79)	14 (13.21)	Reference		Reference
Intermediate	95 (89.62)	11 (10.38)	0.96 (0.41–2.28)	0.932	0.97 (0.40–2.36)	0.943
Low	101 (96.19)	4 (3.81)	0.21 (0.06–0.75)	0.016	0.19 (0.05–0.69)	0.012
				0.017^c		0.012^c
By quartile
Highest	68 (85.00)	12 (15.00)	Reference		Reference
Intermediate high	70 (88.61)	9 (11.39)	0.66 (0.25–1.76)	0.41	0.67 (0.25–1.84)	0.441
Intermediate low	73 (92.41)	6 (7.59)	0.60 (0.22–1.67)	0.33	0.58 (0.21–1.61)	0.294
Lowest	77 (97.47)	2 (2.53)	0.07 (0.01–0.54)	0.011	0.06 (0.01–0.47)	0.008
				0.004^c		0.002^c

^aAdjusted for age only.

^bAdjusted for age, smoking status, pack-year, BMI, D’Amico risk groups and treatment.

^c P for trend.