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. 2019 Sep 28;41(1):91–99. doi: 10.1093/carcin/bgz158

Figure 3.

Figure 3.

(A–C) Scatter-plot analyses comparing the expression of pulmonary miRNAs in sham-exposed mice vs. mice treated with licofelone (A), MCS-exposed mice vs. sham-exposed mice (B), and MCS-exposed mice treated with licofelone versus MCS-exposed mice in the absence of the drug (C). Each dot represents a miRNA, whose expression intensity can be inferred from the position in the x and y axes, according to a color scale (blue, low; yellow, medium; orange to red, high). The diagonal belts indicate the 2-fold variation interval. Symbols falling in the upper area denote miRNA upregulation, and those falling in the lower area denote miRNA downregulation by licofelone. (D–F) Volcano-plot analyses comparing the expression of pulmonary miRNAs in sham-exposed mice versus mice treated with licofelone (D), MCS-exposed mice versus sham-exposed mice (E), and MCS-exposed mice treated with licofelone versus MCS-exposed mice in the absence of the drug (F). The two green vertical lines indicate the 2-fold variation interval, and the horizontal green line indicates the P < 0.05 threshold. miRNAs falling outside these intervals are highlighted in red color.