Table 1.
Bulky DNA adducts and 8-oxo-dGuo levels in the lung of 40 mice aged 10 weeks as related to gender, exposure to MCS since birth and/or treatment with licofelone since weaning.
| Treatment | Gender | DNA adducts/ 108 nucleotides |
8-oxo-dGuo /105nucleotides |
|---|---|---|---|
| Sham | Males | 1.31 ± 0.17 | 1.70 ± 0.22 |
| Females | 1.23 ± 0.15 | 2.11 ± 0.18 | |
| Licofelone | Males | 0.93 ± 0.17 | 1.90 ± 0.27 |
| Females | 1.13 ± 0.18 | 2.06 ± 0.26 | |
| MCS | Males | 17.92 ± 1.77a | 5.03 ± 0.08a |
| Females | 20.04 ± 2.95a | 5.97 ± 0.44a | |
| MCS + licofelone | Males | 8.40 ± 0.79a,c | 1.67 ± 0.07d |
| Females | 10.16 ± 1.53a,b | 2.11 ± 0.25d |
The results are means ± SE within each group of 5 mice. Statistical analysis: aP < 0.001, as compared with sham-exposed mice of the same gender; bP < 0.05, cP < 0.01, and dP < 0.001, as compared with MCS-exposed mice of the same gender.