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. 2020 Aug 28;20:821. doi: 10.1186/s12885-020-07330-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — IL-6 and IL-8 plasma levels in APL-DS patients during ATRA and anthracyclines treatment. a The comparison of the interleukin (IL) -6 plasma levels between patients with APL treated with all-trans retinoic acid (ATRA) and anthracyclines who developed (DS-group; n = 6) or not (non-DS group; n = 11) the differentiation syndrome (DS) were unchanged. b ATRA and anthracyclines significantly reduced the IL-8 levels regardless of the DS development (D7 vs. D0 of DS and non-DS groups combined together, p = 0.002 – Friedman’s test, followed by Dunn’s multiple comparison post-test). The IL-6 (c) and IL-8 (d) D3/D0 and D7/D0 ratios did not differ between DS- and non-DS patients with APL. The horizontal lines represent the median of cytokine plasma concentration in DS- (blue) and non-DS (black) groups