Table 1.
Effects of ATRA and anthracyclines on the secretion of cytokines in APL patients with or without DS
| Cytokine | All patients, (n = 17) | DS group, (n = 6) | Non-DS group, (n = 11) | P-value1 |
|---|---|---|---|---|
| Median (range) | Median (range) | |||
| IL-6 | ||||
| D0 | 6.86 (0.00, 580.19) | 2.93 (0.00, 167.03) | 9.80 (0.61, 580.19) | 0.28 |
| D3 | 4.92 (0.00, 83.74) | 17.39 (0.00, 83.74) | 4.92 (0.00, 26.04) | 0.60 |
| D7 | 0.48 (0.00, 279.10) | 0.26 (0.00, 122.96) | 0.52 (0.00, 279.10) | 0.70 |
| IL-8 | ||||
| D0 | 25.92 (2.63, 147.11) | 23.10 (2.63, 79.64) | 34.16 (6.99, 147.11) | 0.33 |
| D3 | 10.91 (0.83, 238.60) | 12.71 (0.83, 28.99) | 10.62 (3.02, 238.60) | 0.67 |
| D7 | 9.37 (0.00, 26.81) | 6.20 (0.00, 17.24) | 10.91 (0.00, 26.81) | 0.31 |
APL Acute promyelocytic leukemia, DS Differentiation syndrome
1Mann-Whitney U test was used to compare cytokine plasma levels between DS and non-DS groups