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. 2020 Aug 28;17:27. doi: 10.1186/s12977-020-00535-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — IRF4 antisense oligonucleotides decreased proliferation of adult T-cell leukemia. a Resazurin proliferation assay of cells treated for 7 days with 20 μM IRF4#1 normalized to cells treated with Control ASO. b Resazurin proliferation assay at 7 days post-treatment. c Resazurin proliferation time course of cells treated with 5 μM ASOs. d 2 days post-treatment with 10 μM ASOs. e ATL-ED cells 4 days post treatment with varying doses of IRF4#1 ASO. Bands were quantified using BioRad software and presented values are normalized to actin. f 3 days post-treatment with 20 μM IRF4#1 ASO. g 3 days post-treatment with 10 μM ASOs