Table 5.
Overall survival analysis by clinicopathologic variables and body composition factors
| Variable | Analysis | |||
|---|---|---|---|---|
| Univariate | Multivariable | |||
| HR [95% CI] | P value | HR [95% CI] | P value | |
| Sex, male | 1.43 [0.75–2.74] | 0.284 | – | – |
| Age > 60 | 2.88 [1.37–6.04] | 0.005 | 2.51 [1.14–5.56] | 0.023 |
| ASA (I vs II + III + IV) | 2.27 [1.01–5.14] | 0.048 | 1.99 [0.84–4.71] | 0.118 |
| Stage (II vs III) | 2.78 [1.17–6.64] | 0.021 | 2.29 [0.94–5.59] | 0.069 |
| Vascular invasion | 2.14 [1.04–4.40] | 0.039 | 1.90 [1.01–3.57] | 0.030 |
| Lymphatic invasion | 1.97 [0.94–4.13] | 0.074 | – | – |
| Pre-operative CEA level > 5 | 1.63 [0.84–3.13] | 0.147 | – | – |
| Neutrophil lymphocyte ratio ≥ 5 | 0.78 [0.36–1.70] | 0.529 | ||
| Differentiation (well vs moderate +poor) | 0.66 [0.21–1.67] | 0.322 | – | – |
| BMI ≥ 25 | 0.45 [0.19–1.06] | 0.069 | – | – |
| Visceral obesity ≥ 130[33] | 0.63 [0.22–1.32] | 0.220 | – | – |
| Subcutaneous fat area (cm2) > 92a | 0.81 [0.43–1.51] | 0.504 | – | – |
| Abdominal circumference (cm) > 83a | 0.81 [0.44–1.52] | 0.817 | – | – |
| CONUT score > 7[22] | 2.27 [0.53–9.61] | 0.254 | ||
| Pre-sarcopenia, men < 46.4 cm2, women < 37.5 cm 2[32] | 2.38 [1.29–4.41] | 0.004 | 1.92 [1.01–3.57] | 0.047 |
CI confidence interval, ASA American Society of Anesthesiologist physical status, BMI body mass index, CEA carcinoembryonic antigen, CONUT Controlling Nutritional Status
aMedian value