Table 2.
Different class I fusion protein
| Class I virus family | Viruses | Fusion protein | Fusion subunit | Fusion peptide location | Fusion pH |
|---|---|---|---|---|---|
| Retroviridae | Human immunodeficiency virus (HIV) | gp160 | gp41 | N-terminal (mostly) | Neutral/low |
| Orthomyxoviridae | Influenza virus | HA | HA2 | N-terminal | Low |
| Coronaviradae | Severe acute respiratory syndrome (SARS) virus | S | S2 | Internal | Neutral/low |
| Filoviridae | Ebola virus | GP | GP2 | Internal | Low |
| Paramyxoviridae | Sendai virus | F | F1 | N-terminal | Neutral |
| Arenaviridae | Lassa virus | GP, SSP | GP2 | N-terminal | Low |