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. Author manuscript; available in PMC: 2020 Aug 30.
Published in final edited form as: Ultrasound Med Biol. 2019 Sep 14;45(12):3232–3245. doi: 10.1016/j.ultrasmedbio.2019.08.014

Figure 7.

Figure 7.

The balance between intra-tumoral immunosuppressive (cold) and an anti-tumor (hot) tumor microenvironment. The balance between cold and hot TME is dependent on the expression of local concentrations of immune factors (CCTF) in the microenvironment milieu and associated immune cell response. pFUS at >4MPa can start to shift the molecular and cellular balance towards an anti-tumor hot TME within 24 hours and can influence the phenotypes of the local and splenic immune cell populations that could influence treatment effects.