Table 1.
Experimental information of the analgesic effect of MA.
| Animal | Route | Most intense analgesia | ED50 values | Mode of action | Medicine | Method | References |
|---|---|---|---|---|---|---|---|
| Male mice (20-24 g) of the Std:ddY strain Male rats (200-220 g) of the Wistar strain. |
s.c. MA (60 μg/kg) s.c. MA (20 μg/kg) i.c. |
40 min after s.c | 28 μg/kg (95% confidence limit: 11-37) in acetic acid-induced writhing 11 μg/kg (4-28) in tail flick |
Dose-dependent and time-dependent | Mesaconitine hydrobromide | Acetic acid-induced writhing tail-flick | [26].... |
|
| |||||||
| Male Sprague-Dawley rats (250-350 g) | Intracerebral cannulation 10 ng/rats into NRPG 5 ng/rats into NRM 5 ng/rats into PAG |
10 min 5 min 5 min |
Dose-dependent and time-dependent | Mesaconitine hydrobromide | Paw pressure test | [22].... | |
|
| |||||||
| Male rats of the Sprague-Dawley strain (200-250 g) | Intracerebral cannulation 50 and 100 ng/rat into the NRPG 50 ng/rat into the NRGC 50 ng/rat into the PAG 0.5 and 1.0 μg/rat into the lumbar enlargement |
20 to 120 min 20 to 120 min 5 to 120 min 10 to 60 min |
9.1 μg/kg- (95% confidence limits: 5.1-16.2) intravenously | Dose-dependent and time-dependent | Mesaconitine hydrobromide | Tail immersion test | [17].... |
|
| |||||||
| Male NMRI mice (25-30 g) | i.v. | 0.025 (0.021-0.034) | Dose-dependent and time-dependent | Mesaconitine | Formalin test | [18].... | |
Abbreviations: MA: mesaconitine; NRPG: nucleus reticularis paragigantocellularis; NRM: nucleus raphe magnus; NGF: nerve growth factor; PAG: periaqueductal gray.