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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Exp Eye Res. 2020 May 6;196:108061. doi: 10.1016/j.exer.2020.108061

Figure 5.

Figure 5.

Increased AMD-associated protein depositions at the sub-RPE spaces of the adult CXCR5−/−.NRF2−/− mice. The RPE/Choroid/Scleral complexes flatmounts from 6-month-old from WT, DKO, CXCR5 KO, and NRF2 KO mice were used for immunofluorescence (IF) staining for β-amyloid (A), alpha B-crystallin (CRYAB, B), apolipoprotein E (Apo-E, C), complement 5b-9 (C5b-9, D) and ZO-1 (E). The orthogonal projection of z-stacks demonstrates the sub-RPE location of the signals for β-amyloid, CRYAB, and Apo-E, with complement 5b-9 and ZO-1, detected within the RPE cell layer. Nuclei are counterstained with DAPI.