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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Neuropeptides. 2020 Jan 24;80:102024. doi: 10.1016/j.npep.2020.102024

Figure 8. Working hypotheses of two opposing mechanisms that concomitantly drive and silence nerve injury-induced latent sensitization.

Figure 8.

Nerve injury sensitizes a pronociceptive signaling pathway that is tonically silenced by endogenous pain inhibitory NPY-Y1 activity: NMDAR → AC1 → TRPA1/V1. In this model, a Y1 receptor antagonist or NPY knockdown suppresses NPY-Y1, leading to disinhibition of pronociceptive neurotransmitter release, spinal neuron excitability and, ultimately, pain. Line Arrows denote activation/production; Line Dot denotes inhibition.