. Author manuscript; available in PMC: 2020 Aug 30.

Published in final edited form as: Nat Rev Dis Primers. 2019 Jan 7;5(1):1. doi: 10.1038/s41572-018-0051-2

Table 4:

Staging and clinical group classification systems for RMS

Stage	Sites	Invasiveness	Size	Nodes	Metastasis
1	Orbit, H/N (non-PM), GU (non-BP), Biliary	T1 or T2	a or b	N0, N1 or Nx	M0
2	BP, Ext, PM, other	T1 or T2	a	N0 or Nx	M0
3	BP, Ext, PM, other	T1 or T2	a	N1	M0
3	BP, Ext, PM, other	T1 or T2	b	N0, N1 or Nx	M0
4	Any	T1 or T2	a or b	N0, N1 or Nx	M1
Clinical group	Definition
I	Localized disease, completely resected
II	Total gross resection with evidence for regional spread
II A	Grossly resected tumour with microscopic residual
II B	Involved regional LNs, completely resected with no microscopic residual
II C	Involved regional LNs, grossly resected with microscopic residual
III	Biopsy only or partial resection with gross residual
IV	Distant metastatic disease

Abbreviations: H/N, Head and Neck; PM, parameningeal; BP, bladder/prostate; Ext, extremity; T1, primary tumor confined to anatomic site of origin; T2, primary tumor with extension and/or fixation to surrounding tissue; Size a: primary tumor ≤ 5 cm; Size b: primary tumor > 5 cm; N0, regional nodes not involved; N1, regional nodes involved; Nx, status of regional nodes not known; M0, no distant metastasis; M1, metastasis present (includes positive CSF, pleural or peritoneal cytology).