Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Aug 30;7(10):1441–1451. doi: 10.1016/j.eng.2020.07.014

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 THE AUTHORS

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

PMC Copyright notice

Fig. 1 — Potential glycosylation sites in the HCoV-19 S protein and hACE2. (a) 15% SDS-PAGE analysis of the intact and deglycosylated form of the HCoV-19 S protein and hACE2. Molecular weight markers are shown on the left. (b) Schematic representation of the functional subunits and domains of the HCoV-19 S protein (upper panel) and hACE2 (lower panel). CD: connector domain; CH: central helix; CT: cytoplasmic tail; FP: fusion peptide; TM: transmembrane domain; UH: upstream helix; HR1/2: heptad repeat 1/2. Blue indicates the domain or amino acids possibly responsible for interaction between the S protein and hACE2. Potential glycosylation sites within each domain are indicated. Red marks represent identified glycosylated sites in this study. (c, d) Mass spectra of deglycosylated peptide containing (c) N331 and N343 in the HCoV-19 S protein and (d) N90 in hACE2. NTD: N-terminal domain; PD: peptidase domain; CLD: C-terminal collectrin-like domain; de: deamidation.