Table 2.
Summary of glycopeptide and N-glycan identification in HCoV-19 S protein.
Domain | Site | Sequences | Most abundant composition | Most likely structure |
---|---|---|---|---|
S1 | 61 | FSNaVTWF FSNaVTW |
Hex6HexNAc2 | ![]() |
74 | SSVLHSTQDLFLPFFSNaVTWFHAIHVSGTNaGTK SSVLHSTQDLFLPFFSNaVTWFHAIHVSGTNaGTKR HAIHVSGTNaGTKRF |
Fuc1NeuGc2Hex6HexNAc4 | ![]() |
|
122 | TQSLLIVNNaATNVVIK IVNNaATNVVIKVCEF LIVNNaATNVVIKVCEF |
Hex3HexNAc2 | ![]() |
|
149 | VCEFQFCNDPFLGVYYHKNNaK YHKNNaKSWMESEF HKNNaKSWMESEF |
Hex3HexNAc2 | ![]() |
|
165 | VYSSANNaCTFEYVSQPFLMDLEGK SSANNaCTFEY SSANNaCTFEYVSQPF |
Hex4HexNAc2 | ![]() |
|
234 | DLPQGFSALEPLVDLPIGINaITR VDLPIGINaITRF |
Hex5HexNAc2 | ![]() |
|
282 | YNENaGTITDAVDCALDPLSETK | Hex4HexNAc2 | ![]() |
|
331 | FPNaITNLCPFGEVFNaATR RVQPTESIVRFPNaITNLCPF RVQPTESIVRFPNaITNL |
Hex3HexNAc2 | ![]() |
|
343 | FPNITNLCPFGEVFNaATR CPFGEVFNaATRF GEVFNaATRF |
Fuc1NeuGc2Hex5HexNAc4 | ![]() |
|
603 | GGVSVITPGTNaTSNQVAVLY GGVSVITPGTNaTSNQVAVL |
Fuc1Hex3HexNAc2 | ![]() |
|
616 | YQDVNaCTEVPVAIHADQLTPTW QDVNaCTEVPVAIHADQLTPTW QDVNaCTEVPVAIHADQLTPTWRVY YQDVNaCTEVPVAIHADQL QDVNaCTEVPVAIHADQL |
Hex3HexNAc2 | ![]() |
|
657 | AGCLIGAEHVNaNSYECDIPIGAGICASYQTQTNSPR QTRAGCLIGAEHVNaNSYECDIPIGAGICASY IGAEHVNaNSYECDIPIGAGICASY QTRAGCLIGAEHVNaNSY |
Fuc1Hex3HexNAc2 | ![]() |
|
S2 | 709 | SNaNSIAIPTNF | Hex3HexNAc | ![]() |
717 | SNNSIAIPTNaF | Fuc1NeuGc2Hex4HexNAc4 | ![]() |
|
801 | DFGGFNaFSQILPDPSKPSK DFGGFNaFSQILPDPSKPSKR TPPIKDFGGFNaFSQILPDPSK TPPIKDFGGFNaFSQILPDPSKPSK DFGGFNaFSQILPDPSK NaFSQILPDPSKPSKRSF |
Hex3HexNAc2 | ![]() |
|
S2(S2′) | 1074 | NaFTTAPAICHDGK LHVTYVPAQEKNaF |
Hex3HexNAc2 | ![]() |
109 | EGVFVSNaGTHWFVTQR AHFPREGVFVSNaGTHWFVTQR VSNaGTHWF VSNaGTHW |
Hex3HexNAc2 | ![]() |
|
1134b | — | — | — | |
1158 | NaHTSPDVDLGDISGINASVVNIQK YFKNaHTSPDVDLGDISGINASVVNIQK |
Fuc1Hex3HexNAc2 | ![]() |
|
1173 | YFKNHTSPDVDLGDISGINaASVVNIQK NHTSPDVDLGDISGINaASVVNIQK |
Fuc2NeuGc1Hex5HexNAc4 | ![]() |
|
1194 | NLNaESLIDLQELGKYEQYIK NLNaESLIDLQELGK |
Fuc1Hex3HexNAc2 | ![]() |
Glycosylated N sites.
Sites identified only on deglycosylated peptides.