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Changes in lactate release recorded in cortical slices in response to the anaesthetic agents. A) Representative recordings of lactate biosensor currents showing changes in tonic lactate release in response to test drugs. Dashed lines show the extrapolation of lactate biosensor current prior to the application of the drug. B) Summary data illustrating the magnitude of changes in tonic lactate release in response to application of propofol (10 μM), thiopental (10 μM) or etomidate (10 μM).
