Table 2.

Results from the linear mixed effects models assessing Frailty Index change in the LBC1936.

	CRP (mg/l) linear mixed effects model (BIC = −6826)			Fibrinogen (g/L) linear mixed effects model (BIC = −7646)
Fixed effects	β	95% CI	p-Value	β	95% CI	p-Value
Rate of change	0.031	0.008, 0.052	0.006⁎⁎	0.029	0.008, 0.050	0.007⁎⁎
Inflammation	0.002	−0.000, 0.004	0.113	0.011	0.002, 0.020	0.016⁎
Age	0.000	0.000, 0.000	0.000⁎⁎⁎	0.000	0.000, 0.000	0.000⁎⁎⁎
Sex	0.012	−0.000, 0.025	0.055	0.013	0.001, 0.025	0.038⁎
Smoking	0.010	−0.002, 0.022	0.114	0.010	−0.001, 0.022	0.085
Alcohol intake	0.000	−0.000, 0.001	0.800	−0.000	−0.000, 0.000	0.949
Social class	−0.003	−0.009, 0.003	0.343	−0.005	−0.011, 0.001	0.117
Childhood IQ	−0.001	−0.002, −0.001	0.000⁎⁎⁎	−0.001	−0.002, −0.000	0.000⁎⁎⁎
Years of education	−0.004	−0.011, 0.002	0.160	−0.005	−0.011, 0.000	0.096
Inflammation over time	0.001	0.000, 0.002	0.021⁎	0.004	0.001, 0.007	0.014⁎
Age over time	−0.000	−0.000, 0.000	0.115	−0.000	−0.000, 0.000	0.410
Sex over time	−0.003	−0.007, 0.001	0.193	−0.004	−0.008, 0.000	0.092
Smoking over time	0.004	−0.000, 0.008	0.055	0.005	0.001, 0.009	0.009⁎⁎
Alcohol intake over time	−0.000	−0.000, 0.000	0.247	−0.000	−0.000, 0.000	0.385
Social class over time	−0.001	−0.003, 0.001	0.311	−0.001	−0.001, 0.009	0.524
Childhood IQ over time	−0.000	−0.000, 0.000	0.538	−0.000	−0.000, 0.000	0.500
Years of education over time	0.001	−0.002, 0.003	0.583	0.000	−0.002, 0.002	0.702

Note. CRP: C - reactive protein; FI: Frailty Index.

Units: Inflammation: CRP or Fibrinogen respectively; Smoking: Current, Ex, Never; Alcohol intake: units per week; Social class: professional, managerial, skilled non-manual, skilled manual, and semiskilled/unskilled.

^⁎⁎⁎P < .001.

^⁎⁎P < .01.

^⁎P < .05.