Table 3.

Results from the fully-adjusted logistic regression models assessing risk of Fried phenotype transition in the LBC1936.

Variables	CRP (mg/l) logistic regression model (AIC = 548)		Fibrinogen (g/L) logistic regression (AIC = 612)
	Odds ratios (95% CI)	p-Value	Odds ratios (95% CI)	p-Value
Inflammation marker	1.03 (0.93, 1.13)	0.55	0.84 (0.58, 1.20)	0.34
Age	1.21 (0.93, 1.58)	0.16	1.15 (0.89, 1.48)	0.27
Sex	1.01 (0.63, 1.63)	0.96	1.04 (0.66, 1.63)	0.86
Smoking Status	1.19 (0.76, 1.86)	0.44	1.30 (0.86, 1.98)	0.21
Alcohol intake	1.00 (0.98, 1.02)	0.88	1.00 (0.94, 1.02)	0.81
Years of Education	1.07 (0.86, 1.34)	0.52	1.09 (0.88, 1.33)	0.43
Social class	0.89 (0.64, 1.25)	0.51	0.91 (0.64, 1.24)	0.55
Childhood IQ	1.00 (0.98, 1.02)	0.89	1.00 (0.99, 1.08)	0.86
BMI	1.04 (0.98, 1.10)	0.15	1.03 (0.98, 1.08)	0.19
History of diabetes (Yes/No)	0.72 (0.25, 1.86)	0.52	1.24 (0.53, 2.76)	0.60
History of cardiovascular disease (Yes/No)	0.88 (0.50, 1.54)	0.67	0.78 (0.46, 1.31)	0.36
History of high cholesterol (Yes/No)	1.14 (0.69, 1.85)	0.61	1.23 (0.78, 1.93)	0.36
History of stroke (Yes/No)	0.93 (0.19, 3.51)	0.92	1.20 (0.38, 3.49)	0.74
History of thyroid disease (Yes/No)	1.22 (0.57, 2.47)	0.59	0.96 (0.46, 1.89)	0.90
History of cancer (Yes/No)	0.79 (0.35, 1.63)	0.54	0.90 (0.43, 1.77)	0.76
History of Parkinson's disease (Yes/No)	0.00 (N/Aa)	0.98	0.00 (N/Aa)	0.98
History of arthritis (Yes/No)	0.95 (0.61, 1.48)	0.83	0.96 (0.63, 1.45)	0.84
Number of depressive symptoms (HADS)	0.99 (0.88, 1.10)	0.83	0.99 (0.89, 1.10)	0.90

Note. BMI: Body Mass Index; CRP: C - reactive protein; FI: Frailty Index; HADS: Hospital and Anxiety Depression Scale.

Units: Inflammation marker: CRP, Fibrinogen; Smoking: Current, Ex, Never; Alcohol intake: units per week; Social class: professional, managerial, skilled non-manual, skilled manual, and semiskilled/unskilled.

^aUnable to calculate 95% CI due to small sample of Parkinson's disease case.