Table A2.
Baseline differences in characteristics for each category of the Fried phenotype in the LBC1936.
| Variables | Non-frail (n = 478) | Pre-frail (n = 520) | Frail (n = 93) | p-Value |
|---|---|---|---|---|
| CRP mg/L: mean (SD) | 3.2 (2.3) | 3.7 (2.6) | 4.1 (2.6) | <0.001⁎⁎⁎ |
| Fibrinogen g/L: mean (SD) | 3.2 (0.6) | 3.3 (0.7) | 3.6 (0.8) | <0.001⁎⁎⁎ |
| Sex, n (%) Male Female |
245 (51%) 233 (49%) |
259 (50%) 261 (50%) |
44 (47%) 49 (53%) |
0.8 |
| Body mass index (BMI), mean (SD) | 27.1 (3.7) | 28.2 (4.5) | 29.4 (5.8) | <0.001⁎⁎⁎ |
| Smoking status, n (%) Current Ex Never |
39 (8%) 203 (43%) 236 (49%) |
66 (13%) 223 (43%) 231 (44%) |
20 (21%) 39 (42%) 34 (37%) |
<0.01⁎⁎ |
| Alcohol (units per week), mean (SD) | 11.4 (14.8) | 10.2 (13.8) | 7.94 (12.6) | 0.1 |
| Social class, n (%) Professional Managerial Skilled non-manual Skilled manual Semiskilled/Unskilled |
104 (22%) 188 (40%) 104 (22%) 56 (12%) 18 (4%) |
78 (15%) 185 (36%) 122 (24%) 108 (21%) 19 (4%) |
8 (9%) 29 (33%) 20 (23%) 24 (27%) 7 (8%) |
<0.001⁎⁎⁎ |
| Childhood IQ, mean (SD) | 102.1 (14.4) | 98.9 (14.8) | 95.2 (17.4) | <0.001⁎⁎⁎ |
| Years of Education, mean (SD) | 10.9 (1.2) | 10.7 (1.1) | 10.3 (0.9) | <0.001⁎⁎⁎ |
| History of diabetes, n (%) Yes No |
18 (4%) 460 (96%) |
48 (9%) 472 (91%) |
25 (27%) 68 (73%) |
<0.001⁎⁎⁎ |
| History of cardiovascular disease, n (%) Yes No |
92 (19%) 386 (81%) |
134 (26%) 386 (74%) |
42 (45%) 51 (55%) |
<0.001⁎⁎⁎ |
| History of high cholesterol, n (%) Yes No |
147 (31%) 330 (69%) |
192 (37%) 328 (63%) |
47 (51%) 46 (49%) |
<0.01⁎⁎ |
| History of stroke, n (%) Yes No |
15 (3%) 463 (97%) |
30 (6%) 490 (94%) |
9 (10%) 84 (90%) |
<0.05⁎ |
| History of thyroid disease, n (%) Yes No |
35 (7%) 443 (93%) |
53 (10%) 467 (90%) |
11 (12%) 81 (88%) |
0.2 |
| History of cancer, n (%) Yes No |
61 (13%) 417 (87%) |
58 (11%) 462 (89%) |
15 (16%) 78 (84%) |
0.4 |
| History of Parkinson's disease, n (%) Yes No |
2 (>1%) 476 (<99%) |
1 (>1%) 519 (<99%) |
2 (>1%) 91 (<99%) |
<0.05⁎ |
| History of arthritis, n (%) Yes No |
175 (37%) 302 (63%) |
241 (46%) 279 (54%) |
61 (66%) 32 (34%) |
<0.001⁎⁎⁎ |
| Depressive symptoms, mean (SD) | 1.24 (1.48) | 1.69 (1.87) | 3.53 (2.61) | <0.001⁎⁎⁎ |
⁎⁎⁎
P < .001.
⁎⁎
P < .01.
⁎
P < .05.