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. 2020 Aug 14;11:688. doi: 10.3389/fneur.2020.00688

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Copyright © 2020 Zhai, Nasseri, Pöttgen, Gezhelbash, Heesen and Stellmann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Group differences between ambulatory minimally impaired and ambulatory impaired patients with multiple sclerosis (pwMS). Left: Boxplots showing differences between controls minimally ambulatory impaired pwMS [Extended Disability Status Scale (EDSS) <3.5] and severely impaired pwMS (EDSS > 3.5), **p < 0.01, ***p < 0.001, ****p < 0.0001. Right: receiver operating characteristic (ROC) curves of smartphone (red) and ActiGraph (blue) showing the ability of differentiation of levels of ambulatory impairment.