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Modulation of caMC4R pharmacology by caMRAP2a or caMRAP2b. Binding (A,B) and signaling properties (C,D) of caMC4R to α-MSH or ACTH (1–24) upon co-expression of caMRAP2a or caMRAP2b were measured. HEK293T cells were co-transfected with caMC4R/caMRAP2a or caMC4R/caMRAP2b in two different ratios (1:0, and 1:5). Binding and signaling properties were calculated as described in detail in Figures 4, 5, respectively.
