Table 1.
Ligand binding properties of caMC4R.
| MC4R | Bmax % | NDP-MSH | α-MSH | β-MSH | ACTH | THIQ |
|---|---|---|---|---|---|---|
| IC50 (nM) | IC50 (nM) | IC50 (nM) | IC50 (nM) | IC50 (nM) | ||
| hMC4R | 100 | 14.27 ± 2.98 | 280.47 ± 95.49 | 825.87 ± 66.17 | 61.96 ± 17.57 | 164.63 ± 30.15 |
| caMC4R | 34.49 ± 3.43b | 4.87 ± 1.80 | 126.33 ± 8.95 | 442.00 ± 65.43a | 123.03 ± 31.15 | 1260.33 ± 272.61 |
Results are expressed as the mean ± SEM of at least three independent experiments. Human MC4R was used for comparison.
a
Significantly different from the parameter of hMC4R, P < 0.05.
b
Significantly different from the parameter of hMC4R, P < 0.001.