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The effect of caMRAP2a or caMRAP2b on ligand binding properties of caMC4R.
| caMC4R/caMRAP2a or | Bmax | α-MSH | ACTH |
|---|---|---|---|
| caMRAP2b | |||
| IC50 (nM) | IC50 (nM) | ||
| caMC4R (1:0) | 100 | 229.00 ± 79.70 | 235.13 ± 16.70 |
| caMC4R/caMRAP2a (1:5) | 170.74 ± 13.08a | 233.07 ± 44.80 | 6.34 ± 1.07a |
| caMC4R/caMRAP2b (1:5) | 123.58 ± 9.86 | 153.47 ± 33.83 | 10.43 ± 1.12a |
Results are expressed as the mean ± SEM of at least three independent experiments.
Significantly different from the parameter of 1:0, P < 0.001.
