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The effect of caMRAP2a or caMRAP2b on cAMP signaling properties of caMC4R.
| caMC4R/caMRAP2a or | α-MSH | ACTH | ||
|---|---|---|---|---|
| caMRAP2b | ||||
| EC50 (nM) | Rmax | EC50 (nM) | Rmax | |
| caMC4R (1:0) | 1.53 ± 0.15 | 100 | 3.63 ± 1.21 | 100 |
| caMC4R/caMRAP2a (1:5) | 5.93 ± 1.73 | 47.60 ± 7.94a | 1.29 ± 0.34 | 60.18 ± 3.62a |
| caMC4R/caMRAP2b (1:5) | 4.76 ± 1.13 | 85.21 ± 5.27 | 1.75 ± 0.15 | 98.86 ± 4.02 |
Results are expressed as the mean ± SEM of at least three independent experiments.
Significantly different from the parameter of 1:0, P < 0.001.
