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. 2020 Aug 14;10:1424. doi: 10.3389/fonc.2020.01424

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Copyright © 2020 Wei, Song, Zhang, Sun and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mutation and gene expression profiles of PC9 and resistant PC9GR cells. (A) IGV view of EGFR gene from RNA-seq sequence reads showing acquired T790M mutation in the PC9GR cells (marked as C1, C2, C3 in the IGV tracks), which is absent in parental PC9 cells (marked as A1, A2, A3). (B) Principal component analysis for PC9 and PC9GR cells. Component 1 accounts for 82% of variance, and resistant cells have quite different expression profiles from PC9 cells. (C) Volcano plot of differential expression analysis between PC9GR and PC9 cells. Red highlights are genes with false discovery rate <0.05 and fold change >2 (either higher or lower in PC9GR cells). The green numbers on the top are the number of down (469) and up (396) regulated genes in PC9GR cells.