Table 4.

Genetic variants associated with the response to anti-TNF agents.

No	SNP	Gene	Genotypes							HWE		Alleles		OR	95% CI	p-value	Benjamini-Hochberg p-value
				Resp			Nonresp			Resp	Nonresp	Resp	Nonresp
				11	12	22	11	12	22			a2	a2
1.	rs7539036	FCGR3A	n	79	16	0	6	6	0	0.3701	0.2482	16	6	3.63	[1.261–10.425]*	0.01	1.0
			%	83.2	16.8	0	50	50	0			8	25
2.	rs6672453		n	79	16	0	6	6	0	0.3701	0.2482	16	6	3.63	[1.261–10.425]*	0.01	1.0
			%	83.2	16.8	0	50	50	0			8	25
3.	rs373184583		n	79	16	0	6	6	0	0.3701	0.2482	16	6	3.63	[1.261–10.425]*	0.01	1.0
			%	83.2	16.8	0	50	50	0			8	25
4.	rs12128686		n	79	16	0	6	6	0	0.3701	0.2482	16	6	3.63	[1.261–10.425]*	0.01	1.0
			%	83.2	16.8	0	50	50	0			8	25
5.	rs2041747	IL1R	n	90	5	0	9	3	0	0.7922	0.6207	5	3	5.29	[1.178–23.708]*	0.02	1.0
			%	94.7	5.3	0	75	25	0			3	12
6.	rs5746053	TNFRSF1B	n	65	26	4	12	0	0	<0.0001	0.5036	34	0	0.09	[0.005–1.560]	0.02	1.0
			%	68.4	27.4	4.2	100	0	0			18	0
7.	rs1071676	IL1B	n	52	33	10	2	8	2	0.1834	0.2482	53	12	2.59	[1.093–6.113]*	0.03	1.0
			%	54.8	34.7	10.5	16.7	66.8	16.7			28	50
8.	rs1143639		n	52	33	10	2	8	2	0.1834	0.2482	53	12	2.59	[1.093–6.113]*	0.03	1.0
			%	54.8	34.7	10.5	16.7	66.8	16.7			50	50
9.	rs1143637		n	52	33	10	2	8	2	0.1834	0.2482	53	12	2.59	[1.093–6.113]*	0.03	1.0
			%	54.8	34.7	10.5	16.7	66.8	16.7			28	50
10.	rs1143634		n	52	33	10	2	8	2	0.1834	0.2482	53	12	2.59	[1.093–6.113]*	0.03	1.0
			%	54.8	34.7	10.5	16.7	66.8	16.7			28	50
11.	rs7896789	FAS	n	80	14	1	8	2	2	0.7839	0.0543	16	6	3.63	[1.261–10.425]*	0.03	1.0
			%	84.2	14.7	1.1	66.8	16.7	16.7			8	25

SNP, single nucleotide polymorphisms; Resp, responders; Nonresp, nonresponders; HWE, Hardy-Weinberg equilibrium; *95% CI confirming the statistically significant odds ratio (OR); 11 – the first type of homozygous genotype; 22 – the second type of homozygous genotype; 12 – genotype heterozygote; a1 – the first allele; a2 – the second allele.