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. 2020 Aug 14;11:1270. doi: 10.3389/fphar.2020.01270

Figure 1.

Figure 1

The function of glucagon-like peptide 1 (GLP-1) in humans. GLP-1, secreted from the intestinal L-cells, circulates the whole body through the blood. GLP-1 influences energy metabolism and glucose metabolism by regulating the insulin level. In the brain, GLP-1 secreted from intestinal cells can be absorbed into the brain, and the GLP-1 secreted from neurons remains in the cerebrospinal fluid. GLP-1 can control the secretion of various neurotransmitters and the progression of neuroinflammation, and can regulate insulin sensitivity in the brain.