Table 1.
Author/publication year (method) | Center/country | Number of patients | Age | Infusion time | Levosimendan | Control drug |
---|---|---|---|---|---|---|
Momeni et al. (24) (RCT) | Single/Belgium | 36 | 7–977 d | Beginning: the onset of CPBDuration: a maximum of 48 h | Dose: 0.05–0.1 μg/kg/min | Milrinone: 0.4–0.8 μg/kg/min |
Ebade et al. (25) (RCT) | Single/Egypt | 50 | 7–38 m | Beginning: immediately after declamping of the aortaDuration: 24 h from the time of admission to the ICU | Loading: 15 μg/kg over a 10 minContinuous rate: 0.1–0.2 μg/kg/min | Dobutamine: 4–10 μg/kg/min |
Lechner et al. (26) (RCT) | Single/Austria | 40 | <1 y | Beginning: at the time of weaning from CPBDuration: the first post-operative 24 h | Dose: 0.1 μg/kg/min | Milrinone: 0.5 μg/kg/min |
Pellicer et al. (27) (RCT) | Single/Spain | 20 | <30 d | Beginning: before surgeryDuration: 48 h after starting infusion | Dose: 0.1–0.2 μg/kg/min | Milrinone: 0.5–1.0 μg/kg/min |
Ricci et al. (28) (RCT) | Single/Italy | 63 | <30 d | Beginning: at the time of weaning from CPBDuration: 72 h | Dose: 0.1 μg/kg/min | The standard inotropic management |
Wang et al. (29) (CCT) | Single/China | 40 | 3.0–22.0 m | Beginning: after surgery Duration: 24 h | Dose: 0.1–0.2 μg/kg/min | Not levosimendan |
Wang et al. (30) (RCT) | Single/China | 187 | ≤48 m | Beginning: after surgery Duration: 48 h | Dose: 0.05 μg/kg/min | Placebo |