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. 2020 Aug 14;8:456. doi: 10.3389/fped.2020.00456

Table 1.

The basic information of all included trials.

Author/publication year (method) Center/country Number of patients Age Infusion time Levosimendan Control drug
Momeni et al. (24) (RCT) Single/Belgium 36 7–977 d Beginning: the onset of CPBDuration: a maximum of 48 h Dose: 0.05–0.1 μg/kg/min Milrinone: 0.4–0.8 μg/kg/min
Ebade et al. (25) (RCT) Single/Egypt 50 7–38 m Beginning: immediately after declamping of the aortaDuration: 24 h from the time of admission to the ICU Loading: 15 μg/kg over a 10 minContinuous rate: 0.1–0.2 μg/kg/min Dobutamine: 4–10 μg/kg/min
Lechner et al. (26) (RCT) Single/Austria 40 <1 y Beginning: at the time of weaning from CPBDuration: the first post-operative 24 h Dose: 0.1 μg/kg/min Milrinone: 0.5 μg/kg/min
Pellicer et al. (27) (RCT) Single/Spain 20 <30 d Beginning: before surgeryDuration: 48 h after starting infusion Dose: 0.1–0.2 μg/kg/min Milrinone: 0.5–1.0 μg/kg/min
Ricci et al. (28) (RCT) Single/Italy 63 <30 d Beginning: at the time of weaning from CPBDuration: 72 h Dose: 0.1 μg/kg/min The standard inotropic management
Wang et al. (29) (CCT) Single/China 40 3.0–22.0 m Beginning: after surgery Duration: 24 h Dose: 0.1–0.2 μg/kg/min Not levosimendan
Wang et al. (30) (RCT) Single/China 187 ≤48 m Beginning: after surgery Duration: 48 h Dose: 0.05 μg/kg/min Placebo